Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis - (​Jieyuan Zhang, Junjie Guan, Xin Niu, Guowen Hu, Shangchun Guo , Qing Li , Zongping Xie , Changqing Zhang and Yang Wang) - Human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) have emerged as a promising alternative for stem cell transplantation therapy. Exosomes derived from mesenchymal stem cells (MSC-Exos) can play important roles in repairing injured tissues. However, to date, no reports have demonstrated the use of hiPSC-MSC-Exos in cutaneous wound healing, and little is known regarding their underlying mechanisms in tissue repair​.  More..
MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a
rat model of cavernous nerve injury - (Xi Ouyang , Xiaoyan Han , Zehong Chen, Jiafeng Fang, Xuna Huang and Hongbo Wei) - This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model of cavernous nerve injury (CNI). More..
Cellular mechanotransduction: putting all the pieces together again - (Vascular Biology Program, Departments of Pathology and Surgery, Harvard Medical School and Children’s Hospital, Boston, Massachusetts, USA​) - Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch-activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors, cytoskeletal filaments, nuclei, extracellular matrix, and numerous other structures and signaling molecules have all been shown to contribute to the mechanotransduction response. More..
Mesenchymal stem cells: Myths and reality
Angiogenic response upon shock wave treatment of the ischaemic muscle
Scientific Reports - Gene transfection by shock waves
Shock waves induce angiogenesis via exosome release
Improvement of adipose tissue–derived cells by low-energy
extracorporeal shock wave therapy
Novel Approach to Obtain an Activated Fat Graph
UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors
Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation